Can Scorpion Venom Peptides Be Safely Utilized in Cardiovascular Remedy: A Systematic Overview
Summary
Scorpion venom comprises quite a few bioactive peptides with potent cardiovascular results, together with bradykinin-potentiating peptides (BPPs), ion channel modulators, and cardioprotective molecules. These peptides present promise for circumstances corresponding to hypertension, cardiac harm, and arrhythmias. Nevertheless, considerations concerning toxicity, immunogenicity, and off-target actions have restricted their medical growth. This systematic evaluation evaluates the therapeutic potential and security of scorpion venom peptides for cardiovascular functions. A scientific search of PubMed, Scopus, Google Scholar, and Semantic Scholar recognized 1,141 articles. Screening of 463 abstracts and full-text evaluation of 446 eligible research resulted in 17 publications assembly the inclusion standards. Extracted information included mechanisms, efficacy, toxicity, and translational challenges. BPPs persistently demonstrated ACE inhibition, B2 receptor activation, and vital antihypertensive results in animal fashions. A number of peptides additionally confirmed cardioprotective actions by decreasing oxidative stress, irritation, and apoptosis. Ion channel-active peptides influenced cardiac electrophysiology, however many confirmed proarrhythmic dangers attributable to hERG potassium channel blockade or interactions with Nav1.4/1.5 sodium channels. Construction-activity modification research improved specificity and decreased toxicity in chosen variants. Regardless of encouraging preclinical information, no scorpion venom peptide has progressed to medical trials for cardiovascular indications. Main boundaries embody immunogenicity, instability, supply challenges, and security considerations. Scorpion venom peptides signify promising leads for novel cardiovascular therapeutics, significantly as antihypertensive and cardioprotective brokers. Nevertheless, vital toxicological and translational limitations stay. Advances in peptide engineering, focused supply, and medical analysis are essential for safely harnessing their therapeutic potential.
Binorkar S V, Sawant R, Ukey R N, et al. (March 24, 2026) Can Scorpion Venom Peptides Be Safely Utilized in Cardiovascular Remedy: A Systematic Overview. Cureus 18(3): e105747. doi:10.7759/cureus.105747
